Hybrid machine learning to localize atrial flutter substrates using the surface 12-lead electrocardiogram.

ABSTRACT:

Aims

Atrial flutter (AFlut) is a common re-entrant atrial tachycardia driven by self-sustainable mechanisms that cause excitations to propagate along pathways different from sinus rhythm. Intra-cardiac electrophysiological mapping and catheter ablation are often performed without detailed prior knowledge of the mechanism perpetuating AFlut, likely prolonging the procedure time of these invasive interventions. We sought to discriminate the AFlut location [cavotricuspid isthmus-dependent (CTI), peri-mitral, and other left atrium (LA) AFlut classes] with a machine learning-based algorithm using only the non-invasive signals from the 12-lead electrocardiogram (ECG).

Methods and results

Hybrid 12-lead ECG dataset of 1769 signals was used (1424 in silico ECGs, and 345 clinical ECG

SUBMITTER: Luongo G 

PROVIDER: S-EPMC9301972 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature