Left ventricular shape predicts arrhythmic risk in fibrotic dilated cardiomyopathy.

ABSTRACT:

Aims

Remodelling of the left ventricular (LV) shape is one of the hallmarks of non-ischaemic dilated cardiomyopathy (DCM) and may contribute to ventricular arrhythmias and sudden cardiac death. We sought to investigate a novel three dimensional (3D) shape analysis approach to quantify LV remodelling for arrhythmia prediction in DCM.

Methods and results

We created 3D LV shape models from end-diastolic cardiac magnetic resonance images of 156 patients with DCM and late gadolinium enhancement (LGE). Using the shape models, principle component analysis, and Cox-Lasso regression, we derived a prognostic LV arrhythmic shape (LVAS) score which identified patients who reached a composite arrhythmic endpoint of sudden cardiac death, aborted sudden cardiac death, and sustained ventric

SUBMITTER: Balaban G 

PROVIDER: S-EPMC9301973 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature