Determinants of RSV epidemiology following suppression through pandemic contact restrictions.

ABSTRACT:

Introduction

COVID-19 related non-pharmaceutical interventions (NPIs) led to a suppression of RSV circulation in winter 2020/21 in the UK and an off-season resurgence in Summer 2021. We explore how the parameters of RSV epidemiology shape the size and dynamics of post-suppression resurgence and what we can learn about them from the resurgence patterns observed so far.

Methods

We developed an age-structured dynamic transmission model of RSV and sampled the parameters governing RSV seasonality, infection susceptibility and post-infection immunity, retaining simulations fitting the UK's pre-pandemic epidemiology by a set of global criteria consistent with likelihood calculations. From Spring 2020 to Summer 2021 we assumed a reduced contact frequency, returning to pre-pandemic l

SUBMITTER: Koltai M 

PROVIDER: S-EPMC9301974 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature