Aging-related metabolic changes in the extensor digitorum longus muscle of senescence-accelerated mouse-prone 8.

ABSTRACT:

Aim

Sarcopenia - aging-related loss of muscle mass and muscle strength - is a key feature of the frailty model. In the present study, we aimed to elucidate the molecular biological changes associated with aging in the extensor digitorum longus muscle of senescence-accelerated mouse prone 8 mouse model by capillary electrophoresis-mass spectrometry.

Methods

Three groups of senescence-accelerated mouse prone 8 mice were used, namely, 12-week-old (young; n = 5), 40-week-old (elderly; n = 5) and 55-week-old mice (late elderly; n = 5). The extensor digitorum longus muscle was collected. After preliminary analyses, metabolome analysis was carried out by capillary electrophoresis-mass spectrometry. Additionally, we examined whether the activity of enzymes in the metabolic pathway f

SUBMITTER: Hoshino T 

PROVIDER: S-EPMC9302128 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature