Dataset Information

Association Between Maternal Exposure to SO₂ and Congenital Ear Malformations in Offspring: A Population-Based Case-Control Study in Liaoning Province, China.

ABSTRACT: Objectives: To examine associations between maternal sulfur dioxide (SO₂) exposure and congenital ear malformations risk in offspring. Methods: We surveyed 1676 cases with congenital ear malformations and 7950 controls from the Maternal and Child Health Certificate Registry of Liaoning Province between 2010 and 2015. SO₂ concentrations were obtained from the Municipal Environment Protection Bureau of Liaoning Province. Multivariable logistic regression models and Restricted cubic splines (RCS) model were used to assess the aforementioned association. Results: There were significant associations between maternal SO₂ exposure and congenital ear malformations risk during the 3 months before conception (OR _{Q4 vs. Q1} = 1.93, 95% CI = 1.43-2.59) and the 3 months after conception (OR _{Q4 vs. Q1} = 1.63, 95% CI = 1.22-2.18). Similar results were obtained in the analysis of single-month exposure windows, except for the third month before conception and the third month after conception. Moreover, these findings were broadly consistent across subgroups and robust in sensitivity analyses. There were non-linear dose-response associations between SO₂ exposure and congenital ear malformations based on restricted cubic spline model analysis. Conclusion: Maternal SO₂ exposure is associated with increased congenital ear malformations risk in offspring.

SUBMITTER: Yu WJ

PROVIDER: S-EPMC9302193 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Association Between Maternal Exposure to SO2 and Congenital Ear Malformations in Offspring: A Population-Based Case-Control Study in Liaoning Province, China.

Yu Wei-Jun WJ Li Na N Gong Ting-Ting TT Zhang Jia-Yu JY Jiang Yu-Ting YT Zhao Yu-Hong YH Huang Yan-Hong YH Li Jing J Liu Shu S Chen Yan-Ling YL Li Li-Li LL Jiang Cheng-Zhi CZ Chen Zong-Jiao ZJ Wu Qi-Jun QJ

International journal of public health 20220707

Objectives: To examine associations between maternal sulfur dioxide (SO2) exposure and congenital ear malformations risk in offspring. Methods: We surveyed 1676 cases with congenital ear malformations and 7950 controls from the Maternal and Child Health Certificate Registry of Liaoning Province between 2010 and 2015. SO2 concentrations were obtained from the Municipal Environment Protection Bureau of Liaoning Province. Multivariable logistic regression models ...[more]

PMID: 35872708

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Project description:BackgroundWhether hepatitis B virus (HBV) infection of women prior to pregnancy can influence risk of congenital malformations in offspring remains controversial. We assessed the association between them by considering congenital malformations in the aggregate as well as risk of organs systems using a large national sample of Chinese women.MethodsWe performed a record-linkage cohort study of women who participated in National Free Preconception Health Examination Project, between January 1, 2010, and December 31, 2019 for whom data on congenital malformations in their offspring were available from the National Population-Based Birth Defects Surveillance Network. A total of 498,968 linked records were obtained, of which 127,371 were excluded because HBV status before pregnancy was unknown, the records involved multiple pregnancies, or pre-pregnancy examinations were conducted after conception. Based on pre-pregnancy status, mothers were assigned to two categories of HBsAg- or HBsAg+ and, in certain analyses, to three categories of HBsAg-, HBsAg+/HBeAg- or HBsAg+/HBeAg+. Potential associations of serological status with risk of congenital malformations, considered separately or in aggregate, were explored using multilevel logistic regression. Factors that might influence such associations were also explored.FindingsAmong the 371,597 women analyzed, 21,482 (5.78%) were HBsAg+ before pregnancy, and 8333 (2.24%) had a fetus or child diagnosed with congenital malformations, composed of 7744 HBsAg- women and 589 HBsAg+ women. HBsAg+ status was associated with increased risk of congenital malformations in the aggregate (OR 1.14, 95% CI 1.03-1.25) and of cardiovascular malformations specifically (OR 1.18, 95% CI 1.03-1.35). HBsAg+/HBeAg- status was associated with significantly higher risk of cardiovascular malformations (OR 1.19, 95% CI 1.01-1.39) as well as reproductive malformations (OR 1.51, 95% CI 1.02-2.23). Associations between HBsAg+ status before pregnancy and risk of congenital malformations was modified by alanine aminotransferase activity (P interaction < 0.05).InterpretationPrepregnancy HBV infection might be associated with fetal malformations. This association needs further investigation to confirm whether it is a causal association, and assess whether antiviral therapy of women with HBsAg+ planning to conceive might reduce the risk of fetal malformations.FundingThe National Health Commission of the People's Republic of China, China; Science and Technology Department of Sichuan Province, China; and the Ministry of Science and Technology of the People's Republic of China.

Dataset Information

Association Between Maternal Exposure to SO₂ and Congenital Ear Malformations in Offspring: A Population-Based Case-Control Study in Liaoning Province, China.

Publications

Association Between Maternal Exposure to SO<sub>2</sub> and Congenital Ear Malformations in Offspring: A Population-Based Case-Control Study in Liaoning Province, China.

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