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Iodine-catalyzed synthesis of benzoxazoles using catechols, ammonium acetate, and alkenes/alkynes/ketones via C-C and C-O bond cleavage.


ABSTRACT: An efficient metal-free synthesis strategy of benzoxazoles was developed via coupling catechols, ammonium acetate, and alkenes/alkynes/ketones. The developed methodology represents an operationally simple, one-pot and large-scale procedure for the preparation of benzoxazole derivatives using molecular iodine as the catalyst.

SUBMITTER: Aboonajmi J 

PROVIDER: S-EPMC9302334 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Iodine-catalyzed synthesis of benzoxazoles using catechols, ammonium acetate, and alkenes/alkynes/ketones <i>via</i> C-C and C-O bond cleavage.

Aboonajmi Jasem J   Panahi Farhad F   Hosseini Mina Aali MA   Aberi Mahdi M   Sharghi Hashem H  

RSC advances 20220721 32


An efficient metal-free synthesis strategy of benzoxazoles was developed <i>via</i> coupling catechols, ammonium acetate, and alkenes/alkynes/ketones. The developed methodology represents an operationally simple, one-pot and large-scale procedure for the preparation of benzoxazole derivatives using molecular iodine as the catalyst. ...[more]

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