Photosensitized and Photothermal Stimulation of Cellular Membranes by Organic Thin Films and Nanoparticles.

ABSTRACT: Conjugated polymers are increasingly exploited for biomedical applications. In this work, we explored the optical characteristics of conjugated polymers of variable chemical structures at multiple levels relevant to biological interfacing, from fluorescence yield to their influence on cellular membrane potential. We systematically compared the performance of conjugated polymer as cast thin films and as nanoparticles stabilized with amphiphilic polyethylene glycol-poly lactic acid-co-glycolic acid (PEG-PLGA). We assessed in both the dark and under illumination the stability of key optoelectronic properties in various environments, including air and biologically relevant physiological saline solutions. We found that photoreduction of oxygen correlates with nanoparticle and film degradation i

SUBMITTER: Feyen PLC 

PROVIDER: S-EPMC9302485 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature