Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure.

ABSTRACT:

Aims

Elevated concentrations of growth differentiation factor 15 (GDF-15) in patients with heart failure (HF) have been consistently associated with worse clinical outcomes, but what disease mechanisms high GDF-15 concentrations represent remains unclear. Here, we aim to identify activated pathophysiological pathways related to elevated GDF-15 expression in patients with HF.

Methods and results

In 2279 patients with HF, we measured circulating levels of 363 biomarkers. Then, we performed a pathway over-representation analysis to identify key biological pathways between patients in the highest and lowest GDF-15 concentration quartiles. Data were validated in an independent cohort of 1705 patients with HF. In both cohorts, the strongest up-regulated biomarkers in those with hi

SUBMITTER: Ceelen D 

PROVIDER: S-EPMC9302623 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature