Comparison of intranasal and intramuscular naloxone in opioid overdoses managed by ambulance staff: a double-dummy, randomised, controlled trial.

ABSTRACT:

Aims

To measure and evaluate clinical response to nasal naloxone in opioid overdoses in the pre-hospital environment.

Design

Randomised, controlled, double-dummy, blinded, non-inferiority trial, and conducted at two centres.

Setting

Participants were included by ambulance staff in Oslo and Trondheim, Norway, and treated at the place where the overdose occurred.

Participants

Men and women age above 18 years with miosis, rate of respiration ≤8/min, and Glasgow Coma Score <12/15 were included. Informed consent was obtained through a deferred-consent procedure.

Intervention and comparator

A commercially available 1.4 mg/0.1 mL intranasal naloxone was compared with 0.8 mg/2 mL naloxone administered intramuscularly.

Measurements

The primary end-point wa

SUBMITTER: Skulberg AK 

PROVIDER: S-EPMC9302677 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature