Bimodal Fluorescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetimes.

ABSTRACT: Bimodal molecular probes combining nuclear magnetic resonance (NMR) and fluorescence have been widely studied in basic science, as well as clinical research. The investigation of spin phenomena holds promise to broaden the scope of available probes allowing deeper insights into physiological processes. Herein, a class of molecules with a bimodal character with respect to fluorescence and nuclear spin singlet states is introduced. Singlet states are NMR silent but can be probed indirectly. Symmetric, perdeuterated molecules, in which the singlet states can be populated by vanishingly small electron-mediated couplings (below 1 Hz) are reported. The lifetimes of these states are an order of magnitude longer than the longitudinal relaxation times and up to four minutes at 7 T. Moreover, these

SUBMITTER: Yang S 

PROVIDER: S-EPMC9302690 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature