Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.

ABSTRACT:

Objectives

The metabolic dysfunction driven by obesity, including hyperglycemia and dyslipidemia, increases risk for developing at least 13 cancer types. The concept of "metabolic dysfunction" is often defined by meeting various combinations of criteria for metabolic syndrome. However, the lack of a unified definition of metabolic dysfunction makes it difficult to compare findings across studies. This review summarizes 129 studies that evaluated variable definitions of metabolic dysfunction in relation to obesity-related cancer risk and mortality after a cancer diagnosis. Strategies for metabolic dysfunction management are also discussed.

Methods

A comprehensive search of relevant publications in MEDLINE (PubMed) and Google Scholar with review of references was conducted.

SUBMITTER: Karra P 

PROVIDER: S-EPMC9302704 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature