Elevated alpha-fetoprotein in asymptomatic adults: Clinical features, outcome, and association with body composition.

ABSTRACT:

Background and aim

Apparently healthy individuals with elevated serum alpha-fetoprotein (AFP) levels (>7 ng/mL) for unknown causes visit clinics. We investigated their clinical characteristics, outcomes, and relationship with body fat deposition and muscle mass.

Methods

The case group included asymptomatic 137 individuals with "elevated AFP level" (R772) diagnostic code from 2009 to 2018 in a tertiary hospital. The control group enrolled 274 age- and sex-matched patients with <5 cm hepatic hemangiomas. Hepatic, visceral, and psoas muscle adiposity and psoas muscle index (PMI) were measured in the subgroups of 45 cases and 90 controls with pre-contrast computed tomography (CT) images.

Results

The case group (mean age 47.5 years, male 35.8%) showed higher AFP levels (10

SUBMITTER: Jang S 

PROVIDER: S-EPMC9302731 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature