Sleep and affective disorders in relation to Parkinson's disease risk among older women from the Women's Health Initiative.

ABSTRACT:

Objectives

To evaluate sleep and affective (mood/anxiety) disorders as clinical predictors of incident Parkinson's disease (PD) among women ≥65 years of age.

Methods

We performed secondary analyses with available data from the Women's Health Initiative Clinical Trials and Observational Study linked to Medicare claims. Sleep, mood and anxiety disorders at baseline were defined using diagnostic codes. Incident PD was defined using self-reported PD, first PD diagnosis, use of PD medications, and/or deaths attributed to PD. Cox regression was applied to estimate hazard ratios (HR) with 95 % confidence intervals (CI), controlling for socio-demographic/lifestyle/health characteristics. Time-to-event was calculated from baseline (1993-1998) to year of PD event, loss to follow-up, d

SUBMITTER: Beydoun HA 

PROVIDER: S-EPMC9302785 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature