VEGF receptor heterodimers and homodimers are differentially expressed in neuronal and endothelial cell types.

ABSTRACT:

Purpose

We have previously reported that VEGF-B is more potent than VEGF-A in mediating corneal nerve growth in vitro and in vivo, and this stimulation of nerve growth appears to be different from stimulation of angiogenesis by these same ligands, at least in part due to differences in VEGF receptor activation. VEGF signaling may be modulated by a number of factors including receptor number or the formation of receptor hetero- vs. homodimers. In endothelial cells, VEGF receptor heterodimer (VEGR1/R2) activation after ligand binding and subsequent phosphorylation alters the activation of downstream signaling cascades. However, our understanding of these processes in neuronal cell types remains unclear. The purpose of this study was to identify the presence and distribution of VEGF R

SUBMITTER: Sarkar J 

PROVIDER: S-EPMC9302817 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature