Increased fat mass index is associated with decreased glomerular filtration rate estimated from cystatin C. Data from Malmo Diet and Cancer cohort.

ABSTRACT:

Background

This study aims to describe associations of obesity and CKD in a Swedish urban population. The impact of fat mass, from bioimpedance analysis, on eGFR based on cystatin C and/or creatinine is studied.

Methods

5049 participants from Malmö Diet and Cancer Study the cardiovascular arm (MDCS-CV) with available body mass composition (single frequency bioimpedance analysis) and cystatin C measured at baseline were selected. Body mass index (kg/m2) was used to define overweight/obesity. eGFR was calculated using cystatin C (eGFRCYS) and creatinine (eGFRCR) equations: Chronic Kidney Disease Epidemiology Collaboration 2012 (CKD-EPICR, CKD-EPICYS, CKD-EPICR-CYS), eGFRCYS based on Caucasian, Asian, pediatric, and adult cohorts (CAPA), the Lund-Malmö revised equation (LMrev),

SUBMITTER: Laucyte-Cibulskiene A 

PROVIDER: S-EPMC9302820 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature