Estimating dengue transmission intensity from serological data: A comparative analysis using mixture and catalytic models.

ABSTRACT:

Background

Dengue virus (DENV) infection is a global health concern of increasing magnitude. To target intervention strategies, accurate estimates of the force of infection (FOI) are necessary. Catalytic models have been widely used to estimate DENV FOI and rely on a binary classification of serostatus as seropositive or seronegative, according to pre-defined antibody thresholds. Previous work has demonstrated the use of thresholds can cause serostatus misclassification and biased estimates. In contrast, mixture models do not rely on thresholds and use the full distribution of antibody titres. To date, there has been limited application of mixture models to estimate DENV FOI.

Methods

We compare the application of mixture models and time-constant and time-varying catalytic mo

SUBMITTER: Cox V 

PROVIDER: S-EPMC9302823 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature