Modelling Japanese encephalitis virus transmission dynamics and human exposure in a Cambodian rural multi-host system.

ABSTRACT: Japanese encephalitis (JE) is a vector-borne zoonosis and the leading cause of human viral encephalitis in Asia. Its transmission cycle is usually described as involving wild birds as reservoirs and pigs as amplifying hosts. JE is endemic in Cambodia, where it circulates in areas with low pig densities (<70 pigs per km2), and could be maintained in a multi-host system composed of pigs, but also poultry as competent hosts, and dogs, cattle and humans as non-competent hosts. We used a mathematical model representing Japanese encephalitis virus (JEV) transmission in a traditional Cambodian village that we calibrated with field data collected in 3 districts of Kandal province, Cambodia. First, R0 calculations allowed us to assess the capacity of the epidemiological system to be invaded by JEV

SUBMITTER: Ladreyt H 

PROVIDER: S-EPMC9302853 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature