Effect of tafamidis on global longitudinal strain and myocardial work in transthyretin cardiac amyloidosis.

ABSTRACT:

Aims

In patients with transthyretin amyloid cardiomyopathy (ATTR-CM), the effect of tafamidis on myocardial function using serial speckle tracking echocardiography has not been reported. The purpose of this study was to describe the natural history of myocardial function in untreated ATTR-CM and determine the effect of tafamidis on myocardial functional parameters over 12 months of treatment.

Methods and results

A total of 45 subjects with ATTR-CM were retrospectively studied: 23 treated with tafamidis and 22 untreated. Two-dimensional speckle tracking echocardiography was analysed at baseline and 1 year. Serial longitudinal, circumferential, and radial strain, twist, torsion, and myocardial work were measured. Over 1 year, absolute global longitudinal strain (GLS) deteriora

SUBMITTER: Giblin GT 

PROVIDER: S-EPMC9303005 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature