Diagnostic and Prognostic Roles of Thrombospondin-2 in Digestive System Cancers.

ABSTRACT:

Background

Cancers of digestive system have high case-fatality rate. It is important to find more appropriate methods in diagnosing and predicting gastrointestinal malignances. And thrombospondin-2 (TSP-2) was reported to have the functions, although results were not identical. So we performed this meta-analysis to clarify the significance of TSP-2 in this area.

Methods

PubMed, Embase, Web of Science, Cochrane Library, and Clinicaltrial.gov were searched for relevant studies. Data were extracted from these involved records. For the meta-analysis of diagnostic test, bivariate mixed effect model was used to estimate diagnostic accuracy. For prognosis part, HRs and their 95% CIs were pooled to compare the overall survival (OS) and disease-free survival (DFS) between patients wi

SUBMITTER: Gao F 

PROVIDER: S-EPMC9303135 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature