Peak functional ability and age at loss of ambulation in Duchenne muscular dystrophy.

ABSTRACT:

Aim

To correlate the North Star Ambulatory Assessment (NSAA) and timed rise from floor (TRF) recorded at age of expected peak with age at loss of ambulation (LOA) in Duchenne muscular dystrophy (DMD).

Method

Male children with DMD enrolled in the UK North Start Network database were included according to the following criteria: follow-up longer than 3 years, one NSAA record between 6 years and 7 years 6 months (baseline), at least one visit when older than 8 years. Data about corticosteroid treatment, LOA, genotype, NSAA, and TRF were analysed. Age at LOA among the different groups based on NSAA and TRF was determined by log-rank tests. Cox proportional hazard models were used for multivariable analysis.

Results

A total of 293 patients from 13 different centres were i

SUBMITTER: Zambon AA 

PROVIDER: S-EPMC9303180 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature