Neurotransmission and neuromodulation systems in the learning and memory network of Octopus vulgaris.

ABSTRACT: The vertical lobe (VL) in the octopus brain plays an essential role in its sophisticated learning and memory. Early anatomical studies suggested that the VL is organized in a "fan-out fan-in" connectivity matrix comprising only three morphologically identified neuron types; input axons from the median superior frontal lobe (MSFL) innervating en passant millions of small amacrine interneurons (AMs), which converge sharply onto large VL output neurons (LNs). Recent physiological studies confirmed the feedforward excitatory connectivity; a glutamatergic synapse at the first MSFL-to-AM synaptic layer and a cholinergic AM-to-LNs synapse. MSFL-to-AMs synapses show a robust hippocampal-like activity-dependent long-term potentiation (LTP) of transmitter release. 5-HT, octopamine, dopamine and nitr

SUBMITTER: Stern-Mentch N 

PROVIDER: S-EPMC9303212 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature