Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida T
PROVIDER: S-EPMC9303313 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Yoshida Tokuyuki T Morihiro Kunihiko K Naito Yuki Y Mikami Atsushi A Kasahara Yuuya Y Inoue Takao T Obika Satoshi S
Nucleic acids research 20220701 13
Currently, gapmer antisense oligonucleotide (ASO) therapeutics are under clinical development for the treatment of various diseases, including previously intractable human disorders; however, they have the potential to induce hepatotoxicity. Although several groups have reported the reduced hepatotoxicity of gapmer ASOs following chemical modifications of sugar residues or internucleotide linkages, only few studies have described nucleobase modifications to reduce hepatotoxicity. In this study, ...[more]