The Myelin-Weighted Connectome in Parkinson's Disease.

ABSTRACT:

Background

Even though Parkinson's disease (PD) is typically viewed as largely affecting gray matter, there is growing evidence that there are also structural changes in the white matter. Traditional connectomics methods that study PD may not be specific to underlying microstructural changes, such as myelin loss.

Objective

The primary objective of this study is to investigate the PD-induced changes in myelin content in the connections emerging from the basal ganglia and the brainstem. For the weighting of the connectome, we used the longitudinal relaxation rate as a biologically grounded myelin-sensitive metric.

Methods

We computed the myelin-weighted connectome in 35 healthy control subjects and 81 patients with PD. We used partial least squares to highlight the diff

SUBMITTER: Boshkovski T 

PROVIDER: S-EPMC9303520 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature