Ontology highlight
ABSTRACT:
SUBMITTER: Maspero M
PROVIDER: S-EPMC9303573 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Maspero Marco M Dallanoce Clelia C Wängler Björn B Wängler Carmen C Hübner Ralph R
ChemMedChem 20220222 8
In the present study we describe and explain an aberrant behavior in terms of receptor binding profile of a fluorescein-based multimodal imaging agent for gastrin releasing peptide receptor (GRPR) visualization by elucidating a chelating mechanism on sodium ions of its fluorescent dye moiety. This hypothesis is supported by both biological results and spectroscopic analyses of different fluorescein-carrying conjugates and an equally charged set of analogous tartrazine-based GRPR-binding imaging ...[more]