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Parahydrogen-Induced Polarization in Hydrogenation Reactions Mediated by a Metal-Free Catalyst.

ABSTRACT: We report nuclear spin hyperpolarization of various alkenes achieved in alkyne hydrogenations with parahydrogen over a metal-free hydroborane catalyst (HCAT). Being an intramolecular frustrated Lewis pair aminoborane, HCAT utilizes a non-pairwise mechanism of H₂ transfer to alkynes that normally prevents parahydrogen-induced polarization (PHIP) from being observed. Nevertheless, the specific spin dynamics in catalytic intermediates leads to the hyperpolarization of predominantly one hydrogen in alkene. PHIP enabled the detection of important HCAT-alkyne-H₂ intermediates through substantial ¹ H, ¹¹ B and ¹⁵ N signal enhancement and allowed advanced characterization of the catalytic process.

SUBMITTER: Zakharov DO

PROVIDER: S-EPMC9303582 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Parahydrogen-Induced Polarization in Hydrogenation Reactions Mediated by a Metal-Free Catalyst.

Zakharov Danila O DO Chernichenko Konstantin K Sorochkina Kristina K Yang Shengjun S Telkki Ville-Veikko VV Repo Timo T Zhivonitko Vladimir V VV

Chemistry (Weinheim an der Bergstrasse, Germany) 20220119 8

We report nuclear spin hyperpolarization of various alkenes achieved in alkyne hydrogenations with parahydrogen over a metal-free hydroborane catalyst (HCAT). Being an intramolecular frustrated Lewis pair aminoborane, HCAT utilizes a non-pairwise mechanism of H<sub>2</sub> transfer to alkynes that normally prevents parahydrogen-induced polarization (PHIP) from being observed. Nevertheless, the specific spin dynamics in catalytic intermediates leads to the hyperpolarization of predominantly one h ...[more]

PMID: 34928532

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