Systematic review: non-endoscopic surveillance for colorectal neoplasia in individuals with Lynch syndrome.

ABSTRACT:

Background

Individuals with Lynch syndrome are at high risk for colorectal cancer (CRC). Regular colonoscopies have proven to decrease CRC incidence and mortality. However, colonoscopy is burdensome and interval CRCs still occur. Hence, an accurate, less-invasive screening method that guides the timing of colonoscopy would be of important value.

Aim

To outline the performance of non-endoscopic screening modalities for Lynch-associated CRC and adenomas.

Methods

Systematic literature search in MEDLINE and EMBASE to identify studies investigating imaging techniques and biomarkers for detection of CRC and adenomas in Lynch syndrome. The QUADAS-2 tool was used for the quality assessment of included studies.

Results

Seven of 1332 screened articles fulfilled the inclu

SUBMITTER: van Liere ELSA 

PROVIDER: S-EPMC9303645 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature