Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes.

ABSTRACT:

Purpose

While the beneficial effects of medications are numerous, drug-drug interactions may lead to adverse drug reactions that are preventable causes of morbidity and mortality. Our goal was to quantify the prevalence of potential drug-drug interactions in drug prescriptions at Danish hospitals, estimate the risk of adverse outcomes associated with discouraged drug combinations, and highlight the patient types (defined by the primary diagnosis of the admission) that appear to be more affected.

Methods

This cross-sectional (descriptive part) and cohort study (adverse outcomes part) used hospital electronic health records from two Danish regions (~2.5 million people) from January 2008 through June 2016. We included all inpatients receiving two or more medications during thei

SUBMITTER: Leal Rodriguez C 

PROVIDER: S-EPMC9303679 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature