Allergen immunotherapy and/or biologicals for IgE-mediated food allergy: A systematic review and meta-analysis.

ABSTRACT:

Background

There is substantial interest in immunotherapy and biologicals in IgE-mediated food allergy.

Methods

We searched six databases for randomized controlled trials about immunotherapy alone or with biologicals (to April 2021) or biological monotherapy (to September 2021) in food allergy confirmed by oral food challenge. We pooled the data using random-effects meta-analysis.

Results

We included 36 trials about immunotherapy with 2126 mainly child participants. Oral immunotherapy increased tolerance whilst on therapy for peanut (RR 9.9, 95% CI 4.5.-21.4, high certainty); cow's milk (RR 5.7, 1.9-16.7, moderate certainty) and hen's egg allergy (RR 8.9, 4.4-18, moderate certainty). The number needed to treat to increase tolerance to a single dose of 300 mg or 1000 m

SUBMITTER: de Silva D 

PROVIDER: S-EPMC9303769 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature