HCC incidence after hepatitis C cure among patients with advanced fibrosis or cirrhosis: A meta-analysis.

ABSTRACT:

Background and aims

HCV cure reduces but does not eliminate the risk of HCC. HCC surveillance is recommended in populations where the incidence exceeds 1.5% per year. In cirrhosis, HCC surveillance should continue after HCV cure, although it is uncertain if this should be indefinite. For patients with advanced fibrosis (F3), guidelines are inconsistent in their recommendations. We evaluated the incidence of HCC after HCV cure among patients with F3 fibrosis or cirrhosis.

Approach and results

This systematic review and meta-analysis identified 44 studies (107,548 person-years of follow-up) assessing the incidence of HCC after HCV cure among patients with F3 fibrosis or cirrhosis. The incidence of HCC was 2.1 per 100 person-years (95% CI, 1.9-2.4) among patients with cirrhosis

SUBMITTER: Lockart I 

PROVIDER: S-EPMC9303770 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature