Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.

ABSTRACT: Breast cancer is the most frequent malignancy in women worldwide. Basal-like breast cancer (BLBC) is the most aggressive form of this disease, and patients have a poor prognosis. Here, we present data suggesting that the Hippo-transcriptional coactivator with PDZ-binding motif (TAZ) pathway is a key driver of BLBC onset and progression. Deletion of Mob1a/b in mouse mammary luminal epithelium induced rapid and highly reproducible mammary tumorigenesis that was dependent on TAZ but not yes-associated protein 1 (YAP1). In situ early-stage BLBC-like malignancies developed in mutant animals by 2 wk of age, and invasive BLBC appeared by 4 wk. In a human estrogen receptor⁺ luminal breast cancer cell line, TAZ hyperactivation skewed the features of these luminal cells to the basa

SUBMITTER: Soyama H 

PROVIDER: S-EPMC9303858 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature