A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures.

ABSTRACT:

Background

The pulp contains a resident population of stem cells which can be stimulated to differentiate in order to repair the tooth by generating a mineralized extracellular matrix. Over recent decades there has been considerable interest in utilizing in vitro cell culture models to study dentinogenesis, with the aim of developing regenerative endodontic procedures, particularly where some vital pulp tissue remains.

Objectives

The purpose of this review is to provide a structured oversight of in vitro research methodologies which have been used to study human pulp mineralization processes.

Method

The literature was screened in the PubMed database up to March 2021 to identify manuscripts reporting the use of human dental pulp cells to study mineralization. The datas

SUBMITTER: Arora S 

PROVIDER: S-EPMC9303903 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature