Prenatal choline supplementation improves child sustained attention: A 7-year follow-up of a randomized controlled feeding trial.

ABSTRACT: Numerous rodent studies demonstrate developmental programming of offspring cognition by maternal choline intake, with prenatal choline deprivation causing lasting adverse effects and supplemental choline producing lasting benefits. Few human studies have evaluated the effect of maternal choline supplementation on offspring cognition, with none following children to school age. Here, we report results from a controlled feeding study in which pregnant women were randomized to consume 480 mg choline/d (approximately the Adequate Intake [AI]) or 930 mg choline/d during the 3rd trimester. Sustained attention was assessed in the offspring at age 7 years (n = 20) using a signal detection task that showed benefits of maternal choline supplementation in a murine model. Children in the 930 mg/d grou

SUBMITTER: Bahnfleth CL 

PROVIDER: S-EPMC9303951 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature