The association between anti-acetylcholine receptor antibody level and clinical improvement in myasthenia gravis.

ABSTRACT:

Background and purpose

Anti-acetylcholine receptor (AChR) antibodies (ab) in the serum are detected in most patients with generalized myasthenia gravis (MG) and used as a diagnostic tool. The aim of this study was to analyse a possible association between anti-AChR-ab serum levels and clinical improvement of MG.

Methods

The Maastricht University Medical Center is a centre of expertise for the treatment of MG. Between 1997 and 2020, more than 4000 anti-AChR-ab blood samples were measured for clinical care using a quantitative radioimmunoassay technique. These results, in combination with clinical status obtained from the patients' electronic patient files, were retrospectively analysed by a single blinded clinician. Symptoms of MG were classified using the Myasthenia Gravis F

SUBMITTER: Marcuse F 

PROVIDER: S-EPMC9303954 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature