Id3 expression identifies CD4⁺ memory Th1 cells.

ABSTRACT: Memory CD4⁺ T cells play a pivotal role in mediating long-term protective immunity, positioning them as an important target in vaccine development. However, multiple functionally distinct helper CD4⁺ T-cell subsets can arise in response to a single invading pathogen, complicating the identification of rare populations of memory precursor cells during the effector phase of infection and memory CD4⁺ T cells following pathogen clearance and the contraction phase of infection. Furthermore, current literature remains unclear regarding whether a single CD4⁺ memory T-cell lineage gives rise to secondary CD4⁺ T helper subsets or if there are unique memory precursor cells within each helper lineage. A majority of T follicular helper (Tfh) cells

SUBMITTER: Shaw LA 

PROVIDER: S-EPMC9303986 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature