Gd₂O₃-mesoporous silica/gold nanoshells: A potential dual T₁/T₂ contrast agent for MRI-guided localized near-IR photothermal therapy.

ABSTRACT: A promising clinical trial utilizing gold-silica core-shell nanostructures coated with polyethylene glycol (PEG) has been reported for near-infrared (NIR) photothermal therapy (PTT) of prostate cancer. The next critical step for PTT is the visualization of therapeutically relevant nanoshell (NS) concentrations at the tumor site. Here we report the synthesis of PEGylated Gd₂O₃-mesoporous silica/gold core/shell NSs (Gd₂O₃-MS NSs) with NIR photothermal properties that also supply sufficient MRI contrast to be visualized at therapeutic doses (≥10⁸ NSs per milliliter). The nanoparticles have r₁ relaxivities more than three times larger than those of conventional T₁ contrast agents, requiring less concentr

SUBMITTER: Kadria-Vili Y 

PROVIDER: S-EPMC9303993 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature