Apoptotic caspases suppress an MDA5-driven IFN response during productive replication of human papillomavirus type 31.

ABSTRACT: Human papillomaviruses (HPVs) infect the basal proliferating cells of the stratified epithelium, but the productive phase of the life cycle (consisting of viral genome amplification, late gene expression, and virion assembly) is restricted to the highly differentiated suprabasal cells. While much is known regarding the mechanisms that HPVs use to block activation of an innate immune response in undifferentiated cells, little is known concerning how HPV prevents an interferon (IFN) response upon differentiation. Here, we demonstrate that high-risk HPVs hijack a natural function of apoptotic caspases to suppress an IFN response in differentiating epithelial cells. We show that caspase inhibition results in the secretion of type I and type III IFNs that can act in a paracrine manner to induce

SUBMITTER: Huang N 

PROVIDER: S-EPMC9303994 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature