Optogenetic stimulation of pre-Botzinger complex reveals novel circuit interactions in swallowing-breathing coordination.

ABSTRACT: The coordination of swallowing with breathing, in particular inspiration, is essential for homeostasis in most organisms. While much has been learned about the neuronal network critical for inspiration in mammals, the pre-Bötzinger complex (preBötC), little is known about how this network interacts with swallowing. Here we activate within the preBötC excitatory neurons (defined as Vglut2 and Sst neurons) and inhibitory neurons (defined as Vgat neurons) and inhibit and activate neurons defined by the transcription factor Dbx1 to gain an understanding of the coordination between the preBötC and swallow behavior. We found that stimulating inhibitory preBötC neurons did not mimic the premature shutdown of inspiratory activity caused by water swallows, suggesting tha

SUBMITTER: Huff A 

PROVIDER: S-EPMC9304034 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature