ISG15 as a prognostic biomarker in solitary fibrous tumour.

ABSTRACT:

Background

Solitary fibrous tumour (SFT) is a rare mesenchymal malignancy that lacks robust prognostic and predictive biomarkers. Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like modifier, associated with tumour progression, and with poor survival of SFT patients, as previous published by our group. Here, we describe the role of ISG15 in the biology of this rare tumour.

Methods

ISG15 expression was assessed by immunohistochemistry in tissue microarrays from SFT patients and tested for correlation with progression-free survival and overall survival (OS). The effects of ISG15 knockdown or induction were investigated for cancer stem cell (CSC) characteristics and for drug sensitivity in unique in vitro models of SFT.

Results

The prognostic value of ISG15 for OS

SUBMITTER: Mondaza-Hernandez JL 

PROVIDER: S-EPMC9304060 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature