Calcium supplementation during pregnancy and long-term offspring outcome: a systematic literature review and meta-analysis.

ABSTRACT: The World Health Organization currently recommends calcium supplementation for pregnant women, especially those with low calcium intakes, to reduce the risk of hypertension and preeclampsia. We aimed to evaluate the effect of this intervention on selected offspring outcomes. A systematic search was conducted in 11 databases for published randomized controlled trials (RCTs) on the effect of maternal calcium supplementation with or without vitamin D during pregnancy on selected offspring cardiovascular, growth, and metabolic and neurodevelopmental outcomes. Screening of titles and abstracts of 3555 records and full texts of 31 records yielded six RCTs (nine reports, n = 1616). Forest plot analyses were performed if at least two studies presented comparable data on the same outcome. In one st

SUBMITTER: Korhonen P 

PROVIDER: S-EPMC9304138 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature