Alzheimer's disease and cerebrovascular pathology alter inward rectifier potassium (K_IR 2.1) channels in endothelium of mouse cerebral arteries.

ABSTRACT:

Background and purpose

Inward rectifier potassium (K_IR ) channels are key effectors of vasodilatation in neurovascular coupling (NVC). K_IR channels expressed in cerebral endothelial cells (ECs) have been confirmed as essential modulators of NVC. Alzheimer's disease (AD) and cerebrovascular disease (CVD) impact on EC-K_IR channel function, but whether oxidative stress or inflammation explains this impairment remains elusive.

Experimental approach

We evaluated K_IR channel function in intact and EC-denuded pial arteries of wild-type (WT) and transgenic mice overexpressing a mutated form of the human amyloid precursor protein (APP mice, recapitulating amyloid β-induced oxidative stress seen in AD) or a constitutively active form of TGF-

SUBMITTER: Lacalle-Aurioles M 

PROVIDER: S-EPMC9304142 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature