Coenzyme B₁₂ -dependent and independent photoregulation of carotenogenesis across Myxococcales.

ABSTRACT: Light-induced carotenogenesis in Myxococcus xanthus is controlled by the B₁₂ -based CarH repressor and photoreceptor, and by a separate intricate pathway involving singlet oxygen, the B₁₂ -independent CarH paralogue CarA and various other proteins, some eukaryotic-like. Whether other myxobacteria conserve these pathways and undergo photoregulated carotenogenesis is unknown. Here, comparative analyses across 27 Myxococcales genomes identified carotenogenic genes, albeit arranged differently, with carH often in their genomic vicinity, in all three Myxococcales suborders. However, CarA and its associated factors were found exclusively in suborder Cystobacterineae, with carA-carH invariably in tandem in a syntenic carotenogenic operon, except for Cystobacter/Melittangium,

SUBMITTER: Perez-Castano R 

PROVIDER: S-EPMC9304148 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature