Metformin serum concentrations during pregnancy and post partum - A clinical study in patients with polycystic ovary syndrome.

ABSTRACT:

Background and objectives

Metformin is used to treat gestational diabetes. It is also used to treat women with polycystic ovary syndrome and has been shown to prevent late miscarriage and preterm birth. However, increased renal clearance during pregnancy causes a decline in serum concentrations of metformin. The aim of this study was to explore the time course of the pregnancy-related changes in metformin pharmacokinetics and the return to the non-pregnant state.

Method

A subgroup of women in the PregMet2 study (n = 73) agreed to provide serum samples at three time-points in pregnancy (gestational weeks 19, 28 and 32) and once in post partum, (either 2, 4 or 8 weeks after delivery). Serum metformin concentrations were compared using a four-parameter logistic model.

Findin

SUBMITTER: Espnes KA 

PROVIDER: S-EPMC9304251 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature