A population of naive-like CD4⁺ T cells stably polarized to the T_H 1 lineage.

ABSTRACT: T-bet is the lineage-specifying transcription factor for CD4⁺ T_H 1 cells. T-bet has also been found in other CD4⁺ T cell subsets, including T_H 17 cells and Treg, where it modulates their functional characteristics. However, we lack information on when and where T-bet is expressed during T cell differentiation and how this impacts T cell differentiation and function. To address this, we traced the ontogeny of T-bet-expressing cells using a fluorescent fate-mapping mouse line. We demonstrate that T-bet is expressed in a subset of CD4⁺ T cells that have naïve cell surface markers and transcriptional profile and that this novel cell population is phenotypically and functionally distinct from previously described populations of naïve and me

SUBMITTER: Lo JW 

PROVIDER: S-EPMC9304323 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature