Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families.

ABSTRACT: Multiplex families have higher recurrence risk of schizophrenia compared to the families of sporadic cases, but the source of this increased recurrence risk is unknown. We used schizophrenia genome-wide association study data (N = 156,509) to construct polygenic risk scores (PRS) in 1005 individuals from 257 multiplex schizophrenia families, 2114 ancestry-matched sporadic cases, and 2205 population controls, to evaluate whether increased PRS can explain the higher recurrence risk of schizophrenia in multiplex families compared to ancestry-matched sporadic cases. Using mixed-effects logistic regression with family structure modeled as a random effect, we show that SCZ PRS in familial cases does not differ significantly from sporadic cases either with, or without family history (FH) of psych

SUBMITTER: Ahangari M 

PROVIDER: S-EPMC9304393 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature