Peripheral blood DNA methylation profiles predict future development of B-cell Non-Hodgkin Lymphoma.

ABSTRACT: Lack of accurate methods for early lymphoma detection limits the ability to cure patients. Since patients with Non-Hodgkin lymphomas (NHL) who present with advanced disease have worse outcomes, accurate and sensitive methods for early detection are needed to improve patient care. We developed a DNA methylation-based prediction tool for NHL, based on blood samples collected prospectively from 278 apparently healthy patients who were followed for up to 16 years to monitor for NHL development. A predictive score was developed using machine learning methods in a robust training/validation framework. Our predictive score incorporates CpG DNA methylation at 135 genomic positions, with higher scores predicting higher risk. It was 85% and 78% accurate for identifying patients at risk of developing

SUBMITTER: Espin-Perez A 

PROVIDER: S-EPMC9304422 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature