Biological interacting units identified in human protein networks reveal tissue-functional diversification and its impact on disease.

ABSTRACT: Protein-protein interactions (PPI) play an essential role in the biological processes that occur in the cell. Therefore, the dissection of PPI networks becomes decisive to model functional coordination and predict pathological de-regulation. Cellular networks are dynamic and proteins display varying roles depending on the tissue-interactomic context. Thus, the use of centrality measures in individual proteins fall short to dissect the functional properties of the cell. For this reason, there is a need for more comprehensive, relational, and context-specific ways to analyze the multiple actions of proteins in different cells and identify specific functional assemblies within global biomolecular networks. Under this framework, we define Biological Interacting units (BioInt-U) as group

SUBMITTER: Garcia-Vaquero ML 

PROVIDER: S-EPMC9304429 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature