Impaired type I interferon signaling activity implicated in the peripheral blood transcriptome of preclinical Alzheimer's disease.

ABSTRACT:

Background

Subjective or objective subtle cognitive decline (SCD) is considered the preclinical manifestation of Alzheimer's disease (AD), which is a potentially crucial window for preventing or delaying the progression of the disease.

Methods

To explore the potential mechanism of disease progression and identify relevant biomarkers, we comprehensively assessed the peripheral blood transcriptomic alterations in SCD, covering lncRNA, mRNA, and miRNA.

Findings

Dysregulated protein-coding mRNA at both gene and isoform levels implicated impairment in the type I interferon signaling pathway in SCD. Specifically, this pathway was regulated by the transcription factor STAT1 and ncRNAs NRIR and has-miR-146a-5p. The miRNA-mRNA-lncRNA co-expression network revealed hub genes fo

SUBMITTER: Song L 

PROVIDER: S-EPMC9304603 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature