Perivascular spaces as a marker of psychological trauma in depression: A 7-Tesla MRI study.

ABSTRACT:

Introduction

Emerging evidence in depression suggests that blood-brain barrier (BBB) breakdown and elevated inflammatory cytokines in states of persistent stress or trauma may contribute to the development of symptoms. Signal-to-noise ratio afforded by ultra-high field MRI may aid in the detection of maladaptations of the glymphatic system related to BBB integrity that may not be visualized at lower field strengths.

Methods

We investigated the link between glymphatic neuroanatomy via perivascular spaces (PVS) and trauma experience in patients with major depressive disorder (MDD) and in healthy controls using 7-Tesla MRI and a semi-automated segmentation algorithm.

Results

After controlling for age and gender, the number of traumatic events was correlated with total PV

SUBMITTER: Ranti DL 

PROVIDER: S-EPMC9304831 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature