Behavioral features in child and adolescent huntingtin gene-mutation carriers.

ABSTRACT:

Introduction

We compared neuropsychiatric symptoms between child and adolescent huntingtin gene-mutation carriers and noncarriers. Given previous evidence of atypical striatal development in carriers, we also assessed the relationship between neuropsychiatric traits and striatal development.

Methods

Participants between 6 and 18 years old were recruited from families affected by Huntington's disease and tested for the huntingtin gene expansion. Neuropsychiatric traits were assessed using the Pediatric Behavior Scale and the Behavior Rating Inventory of Executive Function. Striatal volumes were extracted from 3T neuro-anatomical images. Multivariable linear regression models were conducted to evaluate the impact of group (i.e., gene nonexpanded [GNE] or gene expanded [GE]), a

SUBMITTER: Reasoner EE 

PROVIDER: S-EPMC9304841 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature