The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia.

ABSTRACT:

Introduction

Schizophrenia's heritability and familial transmission have been known for several decades. The male-specific Y chromosome plays an important role in schizophrenia. Short tandem repeats (STRs)have been recognized as risk genes in the development of schizophrenia. Here, we investigated the association between male schizophrenia and Y-chromosomal STRs loci.

Methods

We recruited 355 patients with schizophrenia and 473 healthy males for physical examination and amplified them with a PowerPlex 21 System fluorescence-labeled composite amplification System. Then, the resultant products were separated by electrophoresis and further detected. Finally, differences in allele and genotype frequency distributions of STR loci were observed.

Results

Our results showed t

SUBMITTER: Yang C 

PROVIDER: S-EPMC9304842 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature